
VU 0364849
CAS No. 1206711-14-9
VU 0364849( VU 0364849 | DMH2 | DMH 2 )
Catalog No. M10756 CAS No. 1206711-14-9
A potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 5.4 nM.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 873 | Get Quote |
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50MG | 1782 | Get Quote |
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100MG | 2250 | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameVU 0364849
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 5.4 nM.
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DescriptionA potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 5.4 nM; also inhibits ALK6 (Ki<1 nM) and ALK2 (Ki=42.77 nM), little to no affinity for ALK4/5, BMPR2, AMPK etc.; blocks SMAD phosphorylation in vitro and in vivo, and enhances liver regeneration after partial hepatectomy.
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In VitroDMH2 decreases expression of Id1 and Id3 and causes growth suppression of three lung cancer cell lines with K-Ras mutation (A549, H157, H727) and three without a K-Ras mutation (H1299, H865, U1752).The combination of DMH2 and PP2 causes significantly greater reduction in Id1 promoter activity and growth inhibition than either agent alone in the A549 cells.
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In VivoDMH2 (0-2 mg/kg, IP, twice daily, for 2 days prior to PH (partial hepatectomy) and for 2 days after PH) increases hepatocyte proliferation from 13.7% to 26.9% at 2 mg/kg. Animal Model:C57BL/6 mice (7-8 weeks, male)Dosage:0.5, 1, 2 mg/kg Administration:IP, twice daily, for 2 days prior to PH and for 2 days after PH (partial hepatectomy)Result:Increased hepatocyte proliferation from 13.7% to 26.9% at 2 mg/kg.
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SynonymsVU 0364849 | DMH2 | DMH 2
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PathwayTGF-beta/Smad
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TargetTGFBR
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RecptorTGFBR
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Research Area——
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Indication——
Chemical Information
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CAS Number1206711-14-9
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Formula Weight451.53
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Molecular FormulaC27H25N5O2
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Purity>98% (HPLC)
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Solubility——
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SMILESN1(CCOC2=CC=C(C3=CN4C(N=C3)=C(C5=CC=NC6=CC=CC=C56)C=N4)C=C2)CCOCC1
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Chemical Name4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl)phenoxy)ethyl)morpholine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tsugawa D, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):549-58.
2. Langenfeld E, et al. Mol Cancer. 2013 Oct 26;12(1):129.
3. Langenfeld E, et al. PLoS One. 2013 Apr 12;8(4):e61256.
molnova catalog



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